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Department of Animal, Dairy and Veterinary Sciences


dbarnard




Dale L. Barnard, Ph.D.
Research Associate Professor

Utah State University
ADVS Department
5600 Old Main Hill
Logan UT 84322-5600

phone   (435) 797-2696
fax   (435) 797-3959
email   honery at cc.usu.edu
 
 
PUBLICATIONS
 
  1. Barnard, D.L., F.B. Johnson, and D.F. Richards. 1985. Comparison of an avidin-biotin immunoassay with three commercially available immunoflueorescence kits for typing of herpes simplex virus. J. Clin. Pathol. 38:1158-1162.


  2. Barnard, D.L., K. Farnes, D.F. Richards, G.E. Croft, and F.B. Johnson. 1986. A new chlamydia transport medium used for transport of herpes simplex viruses. J. Clin. Microbiol. 24:692-695.


  3. Sidwell, R.W., J.H. Huffman, D.L. Barnard, M. Kende, and D.Y. Pifat. 1989. Effects of ribamidine, a 3-carboxamidine derivative of ribavirin on experimentally-induced Phlebovirus infections. Antiviral Res. 10:193-208.


  4. Sidwell, R.W., J.H. Huffman, D.L. Barnard and E.J. Reist. 1989. Effect of phosphonic acid analogs of acyclovir and ganciclovir on in vitro cytomegalovirus infections. Necleosides and Nucleotides. 8:1159-1160.


  5. Barnard, D.L., J.H. Huffman, J.L.B. Morris, R.W. Sidwell and E.J. Reist. 1989. The effects of human cytomegalovirus (HCMV) inhibitory agent, 9-(3'-phosphono-1'-hydroxymethyl-1'-propyloxymethyl) guanine (SR3745), on macromolecular synthesis and in vitro antiviral activity in human diploid cells. The Pharmacologist 31:166.
  6. Barnard, D.L., J.H. Huffman, J.L.B. Morris, S.G. Wood, B.G. Hughes and R.W. Sidwell. 1992. Evaluation of the antiviral activity of anthraquinones, anthrones and anthraquinone against human cytomegalovirus. Antiviral Research. 17:63-77.


  7. Smee, D.F., J.L.B. Morris, D.L. Barnard and A.V. Aerschot. 1992. Selective inhibitation of arthropod-borne and arenaviruses in vitro by 3'-fluoro-3'deoxyadenosine. Antiviral Res. 18:151-162.


  8. Barnard, D.L., J.H. Huffman, J.L.B. Morris, S.G. Wood, B.G. Hughes and R.W. Sidwell. 1992. Evaluation of the antiviral activity of anthraquinones, anthrones and anthraquinone against human cytomegalovirus. Rec. Adv. Chemother. 1:1772-1773
    9. .

  9. Barnard, D.L. and F.B. Johnson. 1992. Topographical analysis of the ADV-G virion using monoclonal antibodies. Arch. Virol. 127:271-289.


  10. Jackson, M.J., L.C. Ellis, J.D. Morrey and D.L. Barnard. 1992. Early detection of Aleutian mink disease virus in mink by polymerase chain reaction. Nor. J. Agr. Sci. Supplement 9:385-387.


  11. Jackson, M.K., L.C. Ellis, J.D. Morrey and D.L. Barnard. 1993. Detection of Aleutian disease virus in natural infections. Faseb J. 7:A502.


  12. Ellis, L.C., M.J. Jackson, J.D. Morrey, D.L. Barnard and Z-Z. Li. 1993. Aleutian disease: Current status and developments. Blue Book of Farming. pp. 4-5.


  13. Barnard, D.L., J.H. Huffman, R.W. Sidwell and L.R. Meyerson. 1993. Mode of action of SP-303 against Respiratory syncytial virus (RSV). Chemotherapy 39:203-211
    14. .

  14. Barnard, D.L., D.F. Smee, J.H. Huffman, R.W. Sidwell and L.R. Meyerson. 1993. Anti-herpesvirus activity and mode of action of SP-303, a novel plant plavenoid. Chemotherapy. 39:212-217.


  15. Barnard, D.L., J.H. Huffman, R.W. Sidwell and E.J. Reist. 1993. Selective inhibition of cytomegaloviruses by 9-(3'-ethyl phosphony-1'-hydroxymethyl-1'-propyloxy-methyl) guanine. Antiviral Res. 22:77-89.


  16. Sidwell, R.W., J.H. Huffman, D.L. Barnard, D.F. Smee, R.P. Warren, M.A. Chirigos, M. Kende and J. Huggins. 1994. Antiviral and immunomodulating inhibitors of experimentally-induced Punt Toro virus infections. Antiviral Res. 25:105-122.


  17. Ubillas, R., S.D. Jolad, R.C. Bruening, M.R. Kernan, S.R. King, D.F. Sesin, M. Barrett, C.A. Stoddart, T. Flaster, J. Kuo, F. Ayala, E. Meza, M. Castanel, D. McMeekin, E. Rozhon, M.S. Tempesta, D. Barnard, D. Smee, R. Sidwell, K. Soike, A. Brazier, S. Safrin, R. Orlando, P.T.M. Kenney, N. Berova, and K. Nakinishi. 1994. SP-303, an antiviral oligomeric protanthocyanidin from the latex of Croton lechleri (Sangre de Drago). Phytomed. 1:77-106.


  18. Sidwell, R.W., J.H. Huffman, D.L. Barnard, D.F. Smee, R.P Warren, M. Kende and J.W. Higgins. 1995. Murine Punta Toro virus infection: a potential model for study of Hantavirus inhibitors. Inter. Antiviral News. 3:33-36.


  19. Barnard, D.L., D.W. Fairbairn, K.L. O'Neill, T.L. Gage and R.W. Sidwell. 1995. Sulfonated anthraquinones as inhibitors of HCMV replication. Antiviral Res. 28:317-329.


  20. Ellis, L.C., M.K. Jackson and D.L. Barnard. 1996. Aleutian Disease: How it is spread and possible treatments. Blue Book of Farming. pp. 18-20.


  21. Jackson, M.K., L.C. Ellis, J.D. Morrey, Z.-Z. Li, D.L. Barnard. 1996. Progression of Aleutian disease in natural and experimentally induced infections of mink. Am. J. Vet. Res. 12:1753-1758.


  22. Huffman, J.H., R.W. Sidwell, D.L. Barnard, A. Morrison, M.I. Otto, C.L. Hill and R.F. Schinazi. 1997. In vitro influenza virus-inhibitory effects of a series of germanium- or silicon-centered polyoxometalates. Antiviral Chem. Chemother. 8:75-83.


  23. Barnard, D.L., C.L. Hill, T.L. Gage, J.L. Matheson, J.H. Huffman, R.W. Sidwell, M.I. Otto and R.F. Schinazi. 1997. Potent inhibition of respiratory syncytial virus by polyoxometalates of several structural classes. Antiviral Res. 34:27-37.


  24. Barnard, D.L., N. Bischofberger, C.U. Kim, J.H. Huffman, R.W. Sidwell, J.P. Dougherty, W. Lew, M.A. Williams, W. Yang. 1997. Acyclic phosphonomethylether nucleoside inhibitors of respiratory viruses. Antiviral Chem. Chemother. 8:223-233.


  25. Sidwell, R.W., J.H. Huffman, D.L. Barnard, K.W. Bailey, M-H. Wong, A. Morrison, T. Syndergard and C.U. Kim. 1998. Inhibition of influenza virus infections in mice by GS4104, an orally effective influenza virus neuraminidase inhibitor. Antiviral Res. 37:107-120.


  26. Player, M.R., D.L. Barnard and P.F. Torrence. 1998. Potent inhibition of respiratory syncytial virus replication using a 2-5A-antisense chimera targeted to signals within the virus genomic RNA. P.N.A.S., USA. (In press).


  27. Lin, Y.M., Flavin, M.T., Schure, R., Chen, F.C., Sidwell, R., Barnard, D.L., Huffman, J.H. and Kern, E.R. 1999. Antiviral activities of biflavonoids. Planta Med. 65:120-125.


  28. Barnard, D.L., R.W. Sidwell, W. Xiao, M.R. Player, S. Adah and P.F. Torrence. 1999. 2-5A-antisense inhibition of respiratory synctytial virus replication. Effects of oligonucleotide structures modifications and RNA target site selection. Antiviral Res. 41:119-134.


  29. Barnard, D.L. 1999. RSV vaccine (subunit) Wyeth-Lederle vaccines. Current opinion in anti-infective drugs. 1:627-631.


  30. Mangel, W.F., Toledo, D.L., Brown, M.T., Ding, J., Sweet, R.,M., Barnard, D.L. and McGrath, W.J. 2000. Chapter 8, Adenovirus proteinase-antiviral target for triple-combination therapy on a single enzyme: Potential inhibitor binding sites. In Handbook for Experimental Therapy, von der Helm, K., Korant, B.D. and Cheronis, J.C. (eds), Vol. 140. Proteases as Targets for Therapy. Springer-Verlage, Berlin, pp 145-158.


  31. Barnard, D.L. 2000. RWJ-270201. Current Opinion in Investigational Drugs 1:421-424.


  32. Barnard, D.L., Stowell, V., Seley, K.L., Hegde, V.R., Subha, R., Rajappan, P., Schneller, S.W. Smee, D.F. and Sidwell, R.W. 2001. Inhibition of measels virus replication by 5'-Nor carbocyclic nucleoside analogs. Antiviral Chem. & Chemother. 12:221-230.


  33. Mangel, W.F., McGrath, W.J., Brown, M.T., Baniecki, M.L., Barnard, D.L., and Pang, Y.-P. 2001. A new form of antiviral combination therapy predicted to prevent resistance from arising, and a model system to test it. Curr. Med. Chem. (In press).


  34. Mangel, W.F., Brown, M.T., Baniecki, M.L., Barnard, D.L., McGrath, W.J. 2001. Prevention of viral drug resistance by novel combination therapy. Current Opinion in Investigational Drugs 2:613-616.


  35. Barnard, D.L. 2000. Pegasys. Current Opinion in Investigational Drugs. In Press.


  36. Sidwell, R,W,, Wong, M,H,, Bailey, K,W,, Barnard, D,L,, Jackson, M,K,, and Smee, D.F. 2001. Utilization of alpha-1-acid glycoprotein levels in the serum as a parameter for in vivo assay of influenza virus inhibitors. Antivir Chem Chemother. 12: 359-365.


  37. Zhang, N., Chen, H.M., Sood, R., Kalicharran, K., Fattom, A.I., Naso, R.B., Barnard, D.L., Sidwell, R.W., and Hosmane, R.S. 2002. In vitro inhibition of the measles virus by novel ring-expanded ('fat') nucleoside analogues containing the imidazo[4,5-e]diazepine ring system. Bioorg. Med. Chem. Lett. 2: 3391-3394.


  38. Barnard, D.L. 2001. Genvir. Curr. Opin. Investig. Drugs. 2: 622-623.


  39. Smee, D.F., Morrison, A.C., Barnard, D.L., and Sidwell, R.W. 2002. Comparison of colorimetric, fluorometric, and visual methods for determining anti-influenza (H1N1 and H3N2) virus activities and toxicities of compounds. J. Virol. Methods. 106:71-79.


  40. Barnard, D,L. 2002. Interferon-alpha. Curr. Opin. Investig. Drugs. 3: 693-697.


  41. Barnard, D.L., Xu, Z.Q., Stowell, V.D., ,Yuan H., Smee, D.F., Samy, R., Sidwell, R.W., Nielsen, M.K., Sun, L., Cao, H., Li, A., Quint, C., Deignan, J., Crabb, J., and Flavin, M.T. 2002. Coumarins and pyranocoumarins, potential novel pharmacophores for inhibition of measles virus replication. Antivir. Chem. Chemother. 13: 39-59.


  42. Barnard, D.L. 2002. Viramidine. Curr. Opin. Investig. Drugs. 3: 1585-1589.


  43. Watson, K.G., Brown, R.N., Cameron, R., Chalmers, D.K., Hamilton, S., Jin, B., Krippner, G.Y., Luttick, A,, McConnell, D.B., Reece, P.A., Ryan, J., Stanislawski, P.C., Tucker, S.P., Wu, W.Y., Barnard, D.L, and Sidwell, R.W. 2003. An orally bioavailable oxime ether capsid binder with potent activity against human rhinovirus. J. Med. Chem. 46: 3181-3184.


  44. Barnard, D.L., Hubbard, V.D., Burton, J., Smee, D.F., Morrey, J.D., Otto, M.J., and Sidwell, R.W. 2004. Inhibition severe acute respiratory syndrome-associated coronavirus (SARSCoV) by calpain inhibitors and ß-D-N4-hydroxycytidine. Antiviral Chem. & Chemother. 15: 15-22.


  45. Barnard, D.L., Hubbard, V.D., Smee, D.F, Sidwell, R.W., Watson, K.G.W., Tucker, S.P.T., and Reece, P.A.R. 2004. In vitro activity of second generation pyridazinyl oxime ethers related to pirodavir: novel capsid-binding inhibitors with potent anti-picornavirus activity. Antimicrob. Agents & Chemother. 48: 1766-1772.


  46. Barnard, D.L. 2004. Inhibitors of measles virus. Antiviral Chem.& Chemother. 15: 111-119.


  47. Gowen, B.B., Barnard, D.L., Smee, D.F., Wong, M.H., Pace, A.M., Jung, K.H., Winslow, S.G., Bailey, K.W., Blatt, L.M., Sidwell, R.W. 2005. Interferon alfacon-1 protects hamsters from lethal pichinde virus infection. Antimicrob Agents Chemother. 49: 2378-2386.


  48. Sidwell, R.W., Bailey, K.W., Wong, M-H., Barnard, D.L., and Smee, D.F., 2005. In vitro and in vivo influenza virus-inhibitory effects of viramidine. Antiviral Research. In Press.


  49. Barnard, D.L. 2006. Current status of anti-picornavirus therapies. Curr. Pharm. Design. 12: 1379-1390.


  50. Sidwell, R.W., Barnard, D.L. 2006. Respiratory Syncytial Virus Infections: Recent Prospects for Control. Antiviral Res. Jun 9; [Epub ahead of print].


  51. Sidwell, R.W., Smee, D.F., Barnard, D.L. 2006. Development of antiviral drugs against avian (H5N1) influenza virus. In I. Wang (ed.), Avian (H5N1) Influenza Virus as a Potential Global Pandemic Agent. Transworld Research Network Publishers, India. In Press.


  52. Barnard, D.L., Day, C.W., Bailey, K., Heiner, M., Montgomery, R., Lauridsen, L., Winslow, S., Hoopes, J., Li, J.K.-K., Lee, J., Carson, D.A., Cottam, H.B., and Sidwell, R.W. 2006. Enhancement of the infectivity of SARS-CoV in BALB/c mice by IMP dehydrogenase inhibitors, including ribavirin. Antiviral Res. 71:53-63.


  53. Chu, C. K., Gadthula, S., Chen, X., Choo, H., Olgen, S., Sidwell, R. W. and Barnard, D. L. 2006. Antiviral activity of nucleoside analogs against SARS-Coronavirus. Antiviral Chem. and Chemother. In Press.