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Department of Animal, Dairy and Veterinary Sciences
 

Donald Smee

Donald F. Smee, PhD
 Research Professor
Institute for Antiviral Research

Utah State University
ADVS Department
5600 Old Main Hill
Logan UT 84322-5600

phone (435)797-2897
fax (435)797-3959
email dsmee at cc.usu.edu

 

  
 
PUBLICATIONS
 
  1. Smee, D.F., R.W. Sidwell, A.C. Morrison, K.W. Bailey, E.Z. Baum, L Ly, and P.C. Wagaman. 2001. Characterization of an influenza A (H3N2) virus resistant to the cyclopentane neuraminidase inhibitor RWJ-270201. Antiviral Res. (in press)


  2. Smee, D.F., K.W. Bailey, M.-H. Wong, and R.W. Sidwell. 2001. Effects of cidofovir on the pathogenesis of a lethal vaccinia virus respiratory infection in mice. Antiviral Res. 52:55-62.


  3. Smee, D.F., M. Bray, and J.W. Huggins. 2001. Intracellular phosphorylation of carbocyclic 3-deazaadenosine, an anti-Ebola virus agent. Antiviral Chem. Chemother. 12:213-220.


  4. Sidwell, R.W., Smee, D.F., J.H. Huffman, D.L. Barnard, J.D. Morrey, K.W. Bailey, W.C. Feng, Y.S. Babu, and K. Bush. 2001. Influence of virus strain, challenge dose, and time of therapy initiation on the in vivo influenza inhibitory effects of RWJ-270201. Antiviral Res. 51:179-187.


  5. Sidwell, R.W., Smee, D.F., K.W. Bailey, and R.A. Burger. 2001. Primary immune system effects of the orally administered cyclopentane neuraminidase inhibitor RWJ-270201 in influenza virus-infected mice. Intl. Immunopharmacol. 1:1211-1218.


  6. Drusano, G.L., S.L. Preston, Smee, D.F., K. Bush, K. Bailey, and R.W. Sidwell. 2001. Pharmacodynamic evaluation of RWJ-270201, a novel neuraminidase inhibitor, in a lethal murine model of influenza predicts efficacy for once-daily dosing. Antimicrob. Agents Chemother. 45:2115-2118.


  7. Sidwell, R.W., Smee, D.F., J.H. Huffman, D.L. Barnard, K.W. Bailey, J.D. Morrey, K. Bush, and Y.S. Babu. 2001. The in vivo influenza-inhibitory effects of the cyclopentane neuraminidase inhibitor RWJ-270201. Antimicrob. Agents Chemother. 45:749-757.


  8. Smee, D.F., J.H. Huffman, A.C. Morrison, D.L. Barnard, and R.W. Sidwell. 2001. Cyclopentane neuraminidase inhibitors with potent in vitro anti-influenza virus activity. Antimicrob. Agents Chemother. 45:743-748.


  9. Smee, D.F., K.W. Bailey, and R.W. Sidwell. 2001. Treatment of lethal vaccinia virus respiratory infections in mice with cidofovir. Antiviral Chem. Chemother. 12:71-76.


  10. Yasuda, S., J.H. Huffman, Smee, D.F., R.W. Sidwell, and K. Miyata. 2000. Spectrum of virus inhibition by consensus interferon YM643. Antiviral Chem. Chemother. 11:337-341.


  11. Sidwell, R.W. and Smee, D.F.. 2000. In vitro and in vivo systems for study of influenza virus inhibitors. Anitiviral Res. 48:1-16.


  12. Smee, D.F., K.W. Bailey, M.-H. Wong, and R.W. Sidwell. 2000. Intranasal treatment of cowpox virus respiratory infections in mice with cidofovir. Antiviral Res. 47:171-177.


  13. Smee, D.F., K.W. Bailey, and R.W. Sidwell. 2000. Treatment of cowpox virus respiratory infections in mice with ribavirin as a single agent or followed sequentially by cidofovir. Antiviral Chem. Chemother. 11:303-309.


  14. Bray, M., M. Martinez, Smee, D.F., D. Kefauver, E. thompson, and J.W. Huggins. 2000. Cidofovir protects mice against lethal aerosol or intranasal cowpox virus challenge. J. Infect. Dis. 181:10-19.


  15. Smee, D.F., R.A. Burger, R.P. Warren, K.W. Bailey, and R.W. Sidwell. 1997. An immunosuppressed mouse model of lethal murine gammaherpesvirus-68 infection for studying potential treatments of Epstein-Barr virus infections in man. Antiviral Chem. Chemother. 8:573-581.


  16. Okleberry, K.M., R.P. Warren, and Smee, D.F.. 1997. Metabolism of ganciclovir and cidofovir in cells infected with drug-resistant and wild-type strains of murine cytomegalovirus. Antiviral Res. 35:83-90.


  17. Smee, D.F., R.W. Sidwell, and B.B. Barnett. 1996. Combination of antiviral immunotoxin and ganciclovir or cidofovir for the treatment of murine cytomegalovirus infections. Antiviral Res. 32:165-171.


  18. Smee, D.F. and E.J. Reist. 1996. Potent anti-murine cytomegalovirus activity and reduced nephrotoxicity of ganciclovir cyclic phosphonate. Antimicrobial Agents Chemother. 40:1964-1966.


  19. Smee, D.F., R.W. Sidwell, J.H. Huffman, J.W. Huggins, M. Kende, and A.J. Verbiscar. 1996. Antiviral activities of tragacanthin polysaccharides on Punta Toro virus infections in mice. Chemotherapy 42:286-293.


  20. Barnet, B.B., Smee, D.F., S.M. Malek, and R.W. Sidwell. 1996. Selective cytotoxicity of ricin A chain immunotoxins towards murine cytomegalovirus-infected cells. Antimicrob. Agents Chemother. 40:470-472.


  21. Smee, D.F. and A.J. Verbiscar. 1995. Effects of plant-derived polysaccharides on murine cytomegalovirus and encephalomyocarditis virus infections in mice. Antiviral Chem. Chemother. 6:385-390.


  22. Barnett, B.B., Smee, D.F., S.M. Malek, and R.W. Sidwell. 1995. Selective cytotoxicity towards cytomegalovirus-infected cells by immunotoxins consisting of gelonin linked to anti-cytomegalovirus antibody. Antiviral Res. 28:93-100.


  23. Smee, D.F., H.A. Alaghamandan, K. Ramasamy, and G.R. Revankar. 1995. Broad-spectrum activity of 8-chloro-7-deazaguanosine against RNA virus infections in mice and rats. Antiviral Res. 26:203-209.


  24. Sidwell, R.W., Smee, D.F., J.H. Huffman, K.W. Bailey, R.P. Warren, R.A. Burger, and C.L. Penney. 1995. Antiviral activity of an immunomodulatory lipophilic desmuramyl MDP analog. Antiviral Res. 26:145-159.


  25. Smee, D.F., S.T. Sugiyama, R.W. Sidwell, and B.B. Barnett. 1995. Effects of monoclonal antibody combined with ganciclovir or (S)-1-[3-hydroxy-(2phosphonyl-methoxy)propyl]cytosine against murine cytomegalovirus infections in cell culture and in severe combined immunodeficient mice. Chemotherapy 41:141-148.


  26. Smee, D.F., B.B. Barnett, R.W. Sidwell, E.J. Reist, and A. Holy. 1995. Antiviral activities of nucleosides and nucleotides against wild-type and drug-resistant strains of murine cytomegalovirus. Antiviral Res. 26:1-9.


  27. Ubillas, R., S.D. Jolad, R.C. Bruening, M.R. Kernan, S.R. King, D.F. Sesin, M. Barrett, C.A. Stoddart, T. Flaster, J.Kuo, F. Ayala, E. Meza, M. Castanel, D. McMeekin, E. Rozhon, M.S. Tempesta, D. Barnard, Smee, D.F., R. Sidwell, K. Soike, A. Brazier, S. Safrin, R. Orlando, P.T.M. Kenney, N. Berova, and K. Nakinishi. 1994. SP-303, an antiviral oligomeric protanthocyanidin from the latex of Croton lechleri (Sangre de Drago). Phytomedicine 1:77-106.


  28. Sidwell, R.W., J.H. Huffman, D.L. Barnard, Smee, D.F., R.P. Warren, M.A. Chiriogs, M. Kende, and J. Huggins. 1994. Antiviral and immunomodulating inhibitors of experimentally-induced Punta Toro virus infections. Antiviral Res. 25:105-122.


  29. Bischofberger, N. M.J.M. Hitchock, M.S. Chen, D.B. Barkhimer, K.C. Cundy, K.M. Kent, S.A. Lacy, W.A. Lee, Z.-H Li, D.B. Mendel, Smee, D.F., and J.L. Smith. 1994. -[((S)-2-Hydroxy-2-oxo-1,2,-dioxaphosphorinan -5-yl)methyl]cytosine, and intracellular prodrug for (S)-1-(3-hydroxy-2-phosphonylmethoxypropl)cytosine with improved therapeutic index in vivo. Antimicrob. Agents Chemother. 38:2387-2391.


  30. Smee, D.F., S.T. Sugiyama, and E.J. Reist. 1994. Nucleotide analogs related to acyclovir and ganciclovir are effective against murine cytomegalovirus infections in BALB/c and severe combined immunodeficient mice. Antimicrob. Agents Chemother. 38:2165-2168.


  31. Gabrielsen, B., J.J. Kirsi, C.D. Kwong, D.A. Carter, C.A. Krauth, L.K. Hanna, J.W. Huggins, T.P. Monath, D.F. Kefauver, H.A. Blough, J.T. Rankin, C.M. Bartz, J.H. Huffman, Smee, D.F., R.W. Sidwell, W.M. Shannon, and J.A. Secrist III. 1994. In vitro and in vivo antiviral (RNA) evaluation of orotidine 5'-monophosphate decarboxylas and inhibitors and analogues including 6-azauridine 5'-(ethylmethoxyalaninyl)phosphate (a 5'-monophosphate prodrug). Antiviral Chem. Chemother. 5:209-220.


  32. Smee, D.F., J.A. Leonhardt, S.T. Sugiyama, and A. Holy. 1994. inhibitors of bovine herpes mammillitis virus infections in cultured cells and in vaginally-infected guinea pigs. Antiviral Chem. Chemother. 5:201-208.


  33. Smee, D.F. and Leonhardt, J.A. 1994. Vaccination against bovine herpes mammillitis virus invections in guinea pigs. Intervirology 37:20-24.


  34. Lillie, J.W., Smee, D.F., J.H. Huffman, L.j. Hansen, R.W. Sidwell, and R. kaddurah-Daouk. 1994. Cyclocreatine (1-carboxymethyl-2-iminoimidazolidine) inhibits the replication of human herpes viruses. Antiviral Res. 23:203-218.


  35. Michael, M.A., H.B. Cottam, Smee, D.F., R.K. Robins, and G.D. Kini. 1993. Alkylpurines as immunopotentiating agents. synthesis and antiviral activity of certain alkylguanines. J. Med. Chem. 36:3431-3436.


  36. Barnard, D.L., Smee, D.F., J.H. Huffman, L.R. Meyerson, and R.W. Sidwell. 1993. Antiherpesvirus activity and mode of action of SP-303, a novel plant flavonoid. Chemotherapy 39:203-211.


  37. Sidwell, R.W., Smee, D.F., R.P. Warren, J.H. Huffman, B.J. Gilbert, R.A. Burger, and F.C. Pearson. 1993. Murine cytomegalovirus-inhibitory effects of ImuVert. Antiviral Res. 20:279-292.


  38. Smee, D.F., J. Gilbert, J.A. Leonhardt, B.B. Barnett, J.H. Huggins, and R.W. Sidwell. 1993. Treatment of lethal Pichinde virus infections in weanling LVG/Lak hamsters with ribavirin, ribamidine, selenazofurin, and ampligen. Antiviral Res. 20:57-70.


  39. Sidwell, R.W., J.H. Huffman, Smee, D.F., J. Gilbert, R.K. Robins, M. kende, and J. Huggins. 1992. Biological response modifiers in combination with antiviral against experimentally-induced virus infections. Can. J. Infect. Dis. 3(Suppl. B):49B-54B.


  40. Smee, D.F., H.B. Cottam, B.S. Sharma, G.D. Kini, G.R. Revankar, E.A. Ojo-Amaize, R.W. Sidwell, W.B. Jolley, and R.K. Robins. 1992. Antiviral and immunomenhancing properties of 7-thia-8-oxoguanosine and related guanosine analogues. Can. J. Infect. Dis. 3(Supple. B):41B-48B.


  41. Robins, R.K., G.R. Revankar, H.B. Cottam, G.D. Kini, Y.S. Sanghvi, K. Ramasamy, N.S. Girgis, Smee, D.F., A.F. Lewis, and W.B. Jolley. 1992. Synthesis of certain aza and deazapurine nucleosides and their modulation of genetic expression. Actual. Chim. Ther. 18:183-191.


  42. Smee, D.F., A. Pease, R.A. Burger, J.H. Huffman, J.D. Morrey, K.Km. Okleberry, R.L. Noble, and R.W. Sidwell. 1992. Ganciclovir treatment of murine cytomegalovirus infection in mice immunosuppressed by prior infection with Friend leukemia virus. Antiviral Chem. Chemother. 3:327-333.


  43. Smee, D.F., J.L.B. Morris, J.A. Leonhardt, J.R. Mead, A. Holy, and R.W. Sidwell. 1992. Treatment of murine cytomegalovirus infections in severe combined immunodeficient mice with ganciclovir, (S)-1-[3-hydroxy-2-(phosphonylmethoxy)propyl}cytosine, interferon and bropirimine. Antimicrob. Agents Chemother. 36:1837-1842.


  44. Sidwell, R.W., J.H. Huffman, Smee, D.F., J. Gilbert, A. Gessaman, A. Pease, R.P. Warren, J. Huggins, and M. Kende. 1992. Potential role of immunomodulators for treatment of Phlebovirus infections in animals. Ann. NY. Acad. Sci. 653:344-355.


  45. Kobe, b., J. Kobe, Smee, D.F., B. Jerman-Blazic-Dzonova, and T. Solmajer. 1992. Use of distance geometry approach for the in vitro antiviral activity evaluation of N-bridgehead C-nuleosides. Eur. J. Med. Chem. 27:259-266.


  46. Sharma, B.S., S. Mhaskar, L. Balazs, A. Jin, and Smee, D.F.. 1992. Immunomodulatory activity of a novel nucleoside, 7-thia-8-oxoguanosine. II. Characterization of induced effector cells and the mechanism of induction. Immunopharmacol. Immunotoxical. 14:21-38.


  47. Smee, D.F., J.L.B. Morris, D.L. Barnard, and A. Van Aerschot. 1992. Selective inhibition of arthropod-borne and arenaviruses in vitro by 3'-fluoro-3'-deoxyadenosine. Antiviral Res. 18:151-162.


  48. Smee, D.F., R.A. Burger, J. Coombs, J.H. Huffman, and R.W. Sidwell. 1991. Progressive murine cytomegalovirus disease after termination of ganciclovir therapy in mice immunosuppressed by cyclophosphamide treatment. J. Infect. Dis. 164:958-961.


  49. Kini, G.D., J.D. Anderson, Y.S. Sanghvi, A.F. Lewis, Smee, D.F., G.R. Revankar, R.K. Robins, and H.B. Cottam. 1991. Synthesis and antiviral activity of certain guanosine analogues in the thiazolo[4,5-d]pyrimidine ring system. J. Med. Chem. 34:3006-3010.


  50. Smee, D.F., Coombs, J.H. Huffman, J.W. Huggins, and R.W. Sidwell. 1991. Combination chemotherapy of Punta Toro virus infections in mice using ribavirin and 7-thia-8-oxoguanosine. Antiviral. Chem. Chemother. 2:93-97.


  51. Sanghvi, Y.S., S.B. Larson, Smee, D.F., G.R. Revankar, and R.K. Robins. 1991. In vivo antiviral activity of 5-amino-1-methyl-3-b-D-ribofuranosyl-pyrazolo [4,3-d]pyrimidin-7(6H)-one and related guanosine analogues prepared from formycin. Nucleosides Nucleotides 10:1417-1427.


  52. Smee, D.F., J.H. Huffman, A. Gessaman, J.W. Huggins, and R.W. Sidwell. 1991. Prophylactic and therapeutic activities of 7-thia-8-oxoguanosine against Punta Toro virus infections in mice. Antiviral Res. 15:229-239.


  53. Smee, D.F., H.A. Alaghamandan, J. Gilbert, R.A. Burger, A. Jin, B.S. Sharma, K. Ramasamy, G.R. Revankar, H.B. Cottam, W.B. Jolley, and R.K. Bobins. 1991. Immunoenhancing properties and antiviral activity of 7-deazaguanosine in mice. Antimicrob. Agents Chemother. 35:152-157.


  54. Smee, D.F., J.H. Huffman, L.L. Hall, J.W. Huggins, and R.W. Sidwell. 1990. Inhibition of Phlebovirus infections in vivo by tiazofurin and selenazofurin. Antiviral Chem. Chemother. 1:211-216.


  55. McGee, D.P.C., J.C. Martin, Smee, D.F., and J.P.H. Verheyden. 1990. Synthesis and antiviral activity of the 3-deaza analogue of 9-[(1,3-dihydroxy-2-propoxy)methyl]-guanine. Nucleosides Nucleotides 9:815-826.


  56. Girgis, N.S., M.A. Michael, Smee, D.F., H.A. Alaghamandan, R.K. Robins, and H.B. Cottam. 1990. Direct c-glycosylation of guanine analogues: the synthesis and antiviral activity of certain 7- and 9-deazaguanine c-nucleosides. J. Med. Chem. 33:2750-2755.


  57. Bontems, R.J., J.D. Anderson, Smee, D.F., A. Jin, H.A. Alaghamandan, B.S. Sharma, W.B. Jolley, R.K. Robins, and h.B. Cottam. 1990. Guanosine analogues. The synthesis of nucleosides of certain 3-substituted 6-aminopyrazolo [3,4-d]pyrimidin-4(5H)-ones as potential immunotherapeutic agents. J. Med. Chem. 33:2174-2178.


  58. Henry, E.M., G.D. Kini, S.B. Larson, R.K. Robins, H.A. Alaghamandan, and Smee, D.F.. 1990. Synthesis and broad spectrum antiviral activity of 7-methyl-8-thioxoguanosine. J. Med. Chem. 33:2127-2130.


  59. Revankar, G.R., N.B. Hanna, K. Ramasamy, S.B. Larson, Smee, D.F., R.A. Finch, T.L. Avery, and R.K. Robins. 1990. Synthesis and in vivo antitumor and antiviral activities of 2'-deoxyribofuranosyl and arabinofuranosyl nucleosides of certain purine-6-sulfenamides, sulfinamides and sulfonamides. J. Heterocycl. Chem. 27:909-918.


  60. Smee, D.F., H.A. Alaghamandan, A. Jin, B.S. Sharma, and W.B. Jolley. 1990. Roles of interferon and natural killer cells in the antiviral activity of 7-thia-8-oxoguanosine against Semliki Forest virus infections in mice. Antiviral Res. 13:91-102.


  61. Smee, D.F., M.L. Barlett, H.A. Alaghamandan, M.M. Jones, G.R. Revankar, and R.K. Robins. 1990. 4,6-Dibenzamidopyrazolo[3,4-d]pyrimidine is a highly selective inhibitor of cytomegalovirus adsorption to cells. Antiviral Res. 13:1-10.


  62. Smee, D.F., H.A. Alaghamandan, M.L. Bartlett, and R.K. Robins. 1990. Intranasal treatment of picornavirus and coronavirus respiratory infections in rodents using 7-thia-8-oxoguanosine. Antiviral Chem. Chemother. 1:47-52.


  63. Smee, D.F., H.A. Alaghamandan, H.B. Cottam, W.B. Jolley, and R.K. Robins. 1990. Antiviral activity of the novel immune modulator 7-thia-8-oxoguanosine. J. Biol. Response Mod. 9:24-32.


  64. Nagahara, K., J.D. Anderson, G.D. Kini, N.K. Dalley, S.B. Larson, Smee, D.F., B.S. Sharma, W.B. Jolley, R.K. Robins, and H.B. Cottam. 1990. Thiazolo[4-5-d]pyrimidine nucleosides. They synthesis of certain 3-b-D-ribofuranosylthiazolo[4-5-d]pyrimidines as potential immunotherapeutic agents. J. Med. Chem. 33:407-415.


  65. Robins, R.K., E. Ojo-Amaize, H.B. Cottam, S. Matsumoto, G.R. Revankar, Smee, D.F., J.M. Fujitaki, R.C. Willis, B. Rubalcava, Z. Parandoosh, L.D. Nord, and W.B. Jolley. 1989. Nucleoside and nucleotide modulation of genetic expression - a new approach to chemotherapy. Adv. Enzyme Regul. 29:97-121.


  66. Smee, D.F., A. Colletti, H.A. Alaghamandan, and L.B. Allen. 1989. Evaluation of continuous cell lines in antiviral studies with murine cytomegalovirus. Arch. Virol. 107:253-260.


  67. Smee, D.F., H.A. Alaghamandan, H.B. Cottam, B.S. Sharma, W.B. Jolley, and R.K. Robins. 1989. Broad-spectrum in vivo antiviral activity of 7-thia-8-oxoguanosine, a novel immunopotentiating agent. Antimicrob. Agents Chemother. 33:1487-1492.


  68. Smee, D.F. 1989. Antiviral activity of the nucleotides analog ribavirin 5'-sulfamate. In: J.C. Martin (ed.), Nucleotide Analogues as Antiviral Agents. American Chemical Society, Washington, D.C., p. 124-139.


  69. Anderson, J.D., Bontems, R.J., S. Geary, H.B. Cottam, S.B. Larson, S.S. Matsumoto, Smee, D.F., and R.K. Robins. 1989. Synthesis of tubercidin, 6-chlorotubercidin and related nucleosides. Nucleosides Nucleotides 8:1201-1216.


  70. Raju, N., Smee, D.F., R.K. Robins, and M.M. Vaghefi. 1989. Synthesis and biological properties of purine and pyrimidine 5'deoxy-5'(dihydroxyphosphinyl)-b-D-ribofuranosyl analogues of AMP, GMP, IMP and CMP. J. Med. Chem. 32:1307-1313.


  71. Ghose, A.K., G.M. Grippen, G.R. Revankar, P.A. McKernan, Smee, D.F., and R.K. Robins. 1989. Analysis of the in vitro antiviral activity of certain ribonucleosides against parainfluenza virus using a novel computer aided receptor modeling procedure. J. Med. Chem. 32:746-756.


  72. Sanghvi, Y.S., S.B. Larson, S.S. Matsumoto, L.D. Nord, Smee, D.F., R.C. Willis, T.L. Avery, R.K. Robins, and G.R. Revankar. 1989. Antitumor and antiviral activity of synthetic a- and b-ribonucleosides of certain substituted pyrimido [5,4-d]pyrimidines: a new synthetic strategy for exocyclic aminonucleosides. J. med. Chem. 32:629-637.


  73. Smee, D.F., P.A. Mckernan, H.A. Alaghamandan, K.B. Frank, K. Ramasamy, G.R. Revankar, and R.K. Robins. 1988. Antiviral activities of 2'-deoxyribofuranosyl and arabinofuranosyl analogs of sangivamycin against retro- and DNA viruses. Antiviral Res. 10:263-278.


  74. Smee, D.F., H.A. Alaghamandan, G.D. Kini, and R.K. Robins. 1988. Antiviral activity and mode of action of ribavirin 5'sulfamate against Semliki Forest virus. Antiviral Res. 10:253-262.


  75. Nord, L.D., R.C. Willis, Smee, D.F., T.A. Riley, G.R. Revankar, and R.K. Robins. 1988. Inhibition of orotdylate decarboxylate by 4(5H)-oxo-1-b-D-ribofuranosylpyrazolo-3,4-d]pyrimidine-3-thiocarboxamide (APR-TC) in B lymphoblasts. Activation by adenosine kinase. Biochem. Pharmacol. 37:4697-4705.


  76. Smee, D.F., M. Chernow, M. Kraft, P.M. Okamoto, and E.J. Prisbe. 1988. Synthesis and anti-herpetic activity of a 2'-fluoroarabinosyl analog of trifluridine. Nucleosides Nucleotides 7:155-165.


  77. Smee, D.F., P.A. McKernan, L.D. Nord, R.C. Willis, C.R. Petrie, T.M. Riley, G.R. Revankar, R.K. Robins, and R.A. Smith. 1987. Novel pyrazolo [3,4-d]pyrimidine nucleoside analog with broad-spectrum antiviral activity. Antimicrob. Agents Chemother. 31:1535-1541.


  78. Frank, K.B., P.A. McKernan, R.A. Smith, and Smee, D.F.. 1987. Visna virus as an in vitro model for human immuinodeficiency virus and inhibitition by ribavirin, phosphonoformate, and 2'3'-dideoxynucleosides. Antimicrob. Agents Chemother. 31:1369-1374.


  79. Duke, A.E., Smee, D.F., M. Chernow, R. Boehme, and T.R. Matthews. 1986. In vitro and in vivo activities of phosphate derivatives of 9-(1,3-dihydroxy-2-propoxymethyl)-guanine against cytomegaloviruses. Antiviral Res. 6:299-308.


  80. Martin, J.C., D.P.C. McGee, G.A. Jeffrey, D.W. Hobbs, Smee, D.F., T.R. Matthews, and J.P.H. Verheyden. 1986. Synthesis and anti-herpes virus activity of acyclic 2'-deoxyguanosine analogues related to 9-[1,3-dihydroxy-2-propoxy)methyl]guanine. J. Med. Chem. 29:1384-1389.


  81. Smee, D.F. and T.R. Matthews. 1986. Metabolism of ribavirin in respiratory syncytial virus-infected and uninfected cells. Antimicrob. Agents Chemother. 30:117-121.


  82. Prisbe, E.J., J.C. Martin, D.P.C. McGee, M.F. Barker, Smee, D.F., A.E. Ducke, T.R. Matthews, and J.P.H. Verheyden. 1986. Synthesis and anti- herpes virus activity of phosphate and phosphonate derivatives of 9-[1,3-dihydroxy-2-propoxy)methyl]guanine. J. Med. Chem. 29:671-675.


  83. Smee, D.F. 1985. Interaction of 9-(1,3-dihydroxy-2-propoxymethyl)guanine with cytosol and mitochondrial deoxyguanosine kinases: possible role in anticytomegalovirus activity. Mol. Cell. Biochem. 69:75-81.


  84. Freitas, V.R., Smee, D.F., M. Chernow, R. Boehme, and T.R. Matthews. 1985. Activity of 9-(1,3-dihydroxy-2-propoxymethyl)guanine compared with that of acyclovir against human, monkey and rodent cytomegaloviruses. Antimicrob. Agents Chemother. 28:240-245.


  85. Smee, D.F., N.L. Campbell, and T.R. Matthews. 1985. Comparative anti-herpesvirus activities of 9-(1,3-dihydroxy-2-propoxymethyl)guanine, acyclovir, and two 2'-fluoropyrimidine nucleosides. Antiviral Res. 5:259-267.


  86. McGee, D.P.C., J.C. Martin, Smee, D.F., T.R. Matthews, and J.P.H. Verheyden. 1985. Synthesis and antiherpes simplex virus activity of 9-[1,3-dihydroxy-2-propylthio)-methyl]guanine. J. Med. Chem. 28:1242-1245.


  87. Smee, D.F., R. Boehme, M. Chernow, B.P. Binko, and T.R. Matthews. 1985. Intracellular metabolism and enzymatic phosphorylation of 9-(1,3-dihydroxy-2-propoxymethyl)-guanine and acyclovir in herpes simplex virus-infected and uninfected cells. Biochem. Pharmacol. 34:1049-1056.


  88. Martin, J.C., G.A. Jeffrey, D.P.C. McGee, M.A. Tippie, Smee, D.F., T.R. Matthews, and J.P.H. Verheyden. 1985. Acyclic analogues of 2'-deoxynucleosides related to 9-[(1,3-dihydroxy-2-propoxy)methyl]guanine as potential antiviral agents. J. Med. Chem. 28:358-362.


  89. Smee, D.F., S.S. Knight, A.E. Duke, W.S. Robinson, T.R. Matthews, and P.L. Marion. 1985. Activities of arabinosyladenine monophosphate and 9-(1,3-dihydroxy-2-propoxy-methyl)guanine against ground squirrel hepatitis virus in vivo as determined by reduction in serum virion-associated DNA polymerase. Antimicrob. Agents Chemother. 27:277-279.


  90. Martin, J.C., Smee, D.F., and J.P.H. Verheyden. 1985. Synthesis of 9-(4-hydroxy-2-oxobutyl)guanine, 9-(2,4-dihydroxybutyl)guanine and related nucleoside and analogues. J. Org. Chem. 50:755-759.


  91. Tippie, M.A., J.C. Martin, Smee, D.F., T.R. Matthews, and J.P.H. Verheyden. 1984. Synthesis and antiherpes simplex virus activity of 9-[4-hydroxy-3-(hydroxymethyl)-1-butyl]guanine. Nucleosides Nucleotides 3:525-535.


  92. Fraser-Smith, E.B., Smee, D.F., and T.R. Matthews. 1983. Efficacy of the acyclic nucleoside 9-(1,3-dihydroxy-2-propoxymethyl)guanine against primary and recrudescent genital herpes simplex virus type 2 infections in guinea pigs. Antimicrob. Agents Chemother. 24:883-887.


  93. Fraser-Smith, E.B., Smee, D.F., and T.R. Matthews. 1983. Lack of efficacy of AMP against recrudescent genital herpes infections in guinea pigs. Antimicrob. Agents Chemother. 24:611-612.


  94. Smee, D.F., J.C. Martin, J.P.H. Verheyden, and T.R. Matthews. 1983. Anti-herpesvirus activity of the acyclic nucleoside 9-(1,3-dihydroxy-2-propoxymethyl)guanine. antimicrob. Agents Chemother. 23:676-682.


  95. Martin, J.C., C.A. Dvorak, Smee, D.F., T.R. Matthews, and J.P.H. Verheyden. 1983. 9-[(1,3-Dihydroxy-2-propoxy)methyl]guanine: a new potent and selective antiherpes agent. J. Med. Chem. 26:759-761.


  96. Smee, D.F., R.W. Sidwell, S.M. Clark, B.B. Barnett, and R.S. Spendlove. 1982. Inhibition of rotaviruses by selected antiviral substances: mechanisms of viral inhibition and in vivo studies. Antimicrob. Agents Chemother. 21:66-73.


  97. Smee, D.F., R.W. Sidwell, S.M. Clark, B.B. Barnett, and R.S. Spendlove. 1981. Inhibition of reoviruses by selected antiviral substances. Antiviral Res. 1:315-323.


  98. Smee, D.F., R.W. Sidwell, S.M. Clark, B.B. Barnett, and R.S. Spendlove. 1981. Inhibition of bluetongue and Colorado tick fever orbiviruses by selected antiviral substances. Antimicrob. Agents Chemother. 20:533-538.


  99. Smee, D.F., R.W. Sidwell, B.B. Barnett, and R.S. Spendlove. 1981. Inhibition of rotaviruses by selected antiviral substances. In: S.D. Acres, A.J. Forman, and H. Fast (eds), Proceedings of the Third International Symposium on Neonatal Diarrhea. Veterinary Infectious Disease Organization, Saskatoon, Saskatchewan, Canada, p. 123-126.


  100. Sidwell, R.W. and Smee, D.F.. 1981. Bovine leukemia virus inhibition in vitro by ribavirin. Antiviral Res. 1:47-53.


  101. Smee, D.F., R.W. Sidwell, B.B. Barnett, R.S. Spendlove, and R.P. Sharma. 1981. Development of antiviral levels of ribavirin in serum and urine from orally treated rats. Chemotherapy 27:12-17.


  102. Smee, D.F., R.W. Sidwell, B.B. Barnett, and R.S. Spendlove. 1981. Bioassay System for determining ribavirin levels in human serum and urine. Chemotherapy 27:1-11.